H5N1沈睡中，慢慢看吧，印尼…
1/3人類H5N1病例在印尼，所以有理由相信印尼的豬也有問題
是地，豬是健康的帶菌者!!
H5N1 Influenza A Infection of Pigs in Indonesia
In areas with H5N1 influenza outbreaks in poultry, the virus was isolated from healthy-appearing pigs.
About one third of all confirmed human H5N1 infections worldwide have occurred in Indonesia. Because pigs are believed to be "mixing vessels" for avian and human influenza viruses, investigators assessed whether pigs in Indonesia were being infected with H5N1 and whether the virus was changing receptor specificity.
The researchers sampled nasal, fecal, and serum samples from healthy-appearing pigs in various districts of the country during three rainy seasons between 2005 and 2009. Among 702 nasal specimens obtained in 2005 and 2007, H5N1 was isolated from 52 (7.4%). Culture-positive pigs showed no signs of influenza-like illness. Among 300 pigs tested in 2008–2009, none were culture positive, although 3 (1%) had neutralizing antibodies to H5N1 virus.
Viral sequences of the hemagglutinin (HA) genes from 39 viruses clustered into three distinct groups that did not reflect geographic origin. Isolates from pigs on the same farm had almost identical genes. Phylogenetic analysis of the HA genes from 13 viruses showed that these viruses were closely related to ones isolated from poultry located near the pigs. Receptor-specificity analysis of representative viruses from each of the three groups revealed that one virus had acquired the ability to recognize a human-type receptor.
Comment: Several findings in this study are noteworthy: (1) Pigs did not show signs of infection, so they could serve as asymptomatic reservoir hosts; (2) H5N1 appeared to have entered pig populations at least three times, probably from poultry nearby, and was transmitted among pigs; and (3) the virus acquired mutations in pigs that could potentially increase its ability to infect humans and spread among them. Transport of pigs for market provides a mechanism by which the virus can move silently from one place to another.
— Mary E. Wilson, MD
Published in Journal Watch Infectious Diseases October 6, 2010
Citation(s):
Nidom CA et al. Influenza A (H5N1) viruses from pigs, Indonesia. Emerg Infect Dis 2010 Oct; 16:1515.
* Medline abstract (Free)
是地，豬是健康的帶菌者!!
H5N1 Influenza A Infection of Pigs in Indonesia
In areas with H5N1 influenza outbreaks in poultry, the virus was isolated from healthy-appearing pigs.
About one third of all confirmed human H5N1 infections worldwide have occurred in Indonesia. Because pigs are believed to be "mixing vessels" for avian and human influenza viruses, investigators assessed whether pigs in Indonesia were being infected with H5N1 and whether the virus was changing receptor specificity.
The researchers sampled nasal, fecal, and serum samples from healthy-appearing pigs in various districts of the country during three rainy seasons between 2005 and 2009. Among 702 nasal specimens obtained in 2005 and 2007, H5N1 was isolated from 52 (7.4%). Culture-positive pigs showed no signs of influenza-like illness. Among 300 pigs tested in 2008–2009, none were culture positive, although 3 (1%) had neutralizing antibodies to H5N1 virus.
Viral sequences of the hemagglutinin (HA) genes from 39 viruses clustered into three distinct groups that did not reflect geographic origin. Isolates from pigs on the same farm had almost identical genes. Phylogenetic analysis of the HA genes from 13 viruses showed that these viruses were closely related to ones isolated from poultry located near the pigs. Receptor-specificity analysis of representative viruses from each of the three groups revealed that one virus had acquired the ability to recognize a human-type receptor.
Comment: Several findings in this study are noteworthy: (1) Pigs did not show signs of infection, so they could serve as asymptomatic reservoir hosts; (2) H5N1 appeared to have entered pig populations at least three times, probably from poultry nearby, and was transmitted among pigs; and (3) the virus acquired mutations in pigs that could potentially increase its ability to infect humans and spread among them. Transport of pigs for market provides a mechanism by which the virus can move silently from one place to another.
— Mary E. Wilson, MD
Published in Journal Watch Infectious Diseases October 6, 2010
Citation(s):
Nidom CA et al. Influenza A (H5N1) viruses from pigs, Indonesia. Emerg Infect Dis 2010 Oct; 16:1515.
* Medline abstract (Free)
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