睡得好，cholesterol少

只有女性嗎? 男性應該也一樣吧

You Snooze, You Win

A large, longitudinal cohort study demonstrated a convincing association between short sleep duration and hypercholesterolemia in young women.

Adequate sleep is critical for optimal health and functioning, yet insufficient sleep remains a widespread public health problem in children and adults worldwide. Cross-sectional studies have suggested that short sleep duration is associated with hyperlipidemia, particularly in older adult women. Now, researchers have conducted the first longitudinal study of this association. They performed a multivariable analysis of data collected during three interviews conducted over a 6-year period from students who were in grades 7 through 12 at baseline. Of 14,257 participants, 618 reported receiving a diagnosis of high cholesterol at the final visit.

Shorter self-reported sleep duration at the first or second visit was significantly associated with subsequent hyperlipidemia diagnosis in young women (adjusted odds ratio, 0.85; 95% confidence interval, 0.75–0.96), with a similar but nonsignificant trend in men (AOR, 0.91; 95% CI, 0.79–1.05). The findings were not significantly altered after adjustments for relevant demographic and health covariates including physical activity, emotional stress, and body weight. Limitations included reliance on self-reported sleep duration and hyperlipidemia history, missing data, and loss to follow-up.

Comment: This well-designed and executed study revealed a convincing association between short sleep duration and hyperlipidemia in young women. Atherosclerosis begins early in life, so reducing risk factors for vascular disease in adolescence could reduce morbidity and mortality from heart disease and stroke in later life. Additional research is needed to confirm the association between sleep duration and hypercholesterolemia by direct prospective measurements and correlation of sleep duration and lipid levels, and to clarify why this association appears to be stronger in women than in men. Future intervention studies could then determine whether lengthened sleep can lower lipid levels and alter cardiovascular and cerebrovascular outcomes. Clinicians should strive to diagnose and treat common clinical sleep problems in adolescents, addressing inadequate sleep hygiene and diagnosing circadian disorders (e.g., delayed sleep-phase syndrome). Consideration of lipid screening in teenagers and young adults with sleep disorders is also reasonable.

— Erik St. Louis, MD

Dr. St. Louis is Associate Professor of Neurology and Senior Associate Consultant, Mayo Center for Sleep Medicine, Division of Pulmonary/Critical Care Medicine, Departments of Medicine and Neurology, Mayo Clinic, Rochester, MN.

Published in Journal Watch Neurology October 19, 2010

Citation(s):

Gangwisch JE et al. Short sleep duration as a risk factor for hypercholesterolemia: Analyses of the National Longitudinal Study of Adolescent Health. Sleep 2010 Jul 1; 33:956.

• Medline abstract (Free)