住院的人，大便有MDR-GNB
住院的人，非因infectious diarrhea來住院，32%大便會有mdr-GNB
裏面有10%的人從沒住過院(這種也會…)
全文找不到，不知道MDR的定義
Prevalence of Multidrug-Resistant Gram-Negative Pathogens
Fecal carriage of such pathogens was common among patients hospitalized for diarrhea in France, particularly those with recent hospitalization, antibiotic therapy, or nursing home residence.
A rapid rise in multidrug-resistant (MDR) gram-negative pathogens has been observed worldwide. Such pathogens can be acquired under common circumstances — for example, during travel (JW Infect Dis Sep 29 2010) — and antibiotic therapy is assumed to be the selective pressure driving further spread of resistant clones. Fecal colonization may be a risk factor for subsequent clinically apparent infections. However, little is known about the prevalence of MDR pathogens in the fecal flora of patients admitted to the hospital.
To investigate this issue, researchers collected stool specimens from 303 patients who were hospitalized in France with acute diarrhea during a nonoutbreak situation in the fall of 2009. The specimens were screened for gram-negative bacilli resistant to at least three antibiotic families. These bacteria were isolated using selective growth media and were further characterized by molecular methods.
Ninety-six patients (32%) harbored such MDR pathogens. Among these patients, 90% had been hospitalized, had been treated at a healthcare center, or had lived in a nursing home during the previous year; 59% had been prescribed antibiotics during the previous month. However, 10% of those carrying MDR bacteria had never been hospitalized before. Sixteen percent of the study population carried extended-spectrum β-lactamase–producing strains, and 5% carried carbapenemase-producing strains. The most commonly isolated MDR pathogens were Enterobacter cloacae and Escherichia coli.
Comment: Fecal colonization with MDR bacteria appears to be far more widespread than previously thought. The high level of fecal carriage has enormous potential for further selection of resistant clones in the course of antibiotic therapy and underlines the importance of proper hygiene measures to prevent the rapid spread of MDR pathogens.
— Thomas Glück, MD
Published in Journal Watch Infectious Diseases December 15, 2010
Citation(s):
Vidal-Navarro L et al. Faecal carriage of multidrug-resistant Gram-negative bacilli during a non-outbreak situation in a French university hospital. J Antimicrob Chemother 2010 Nov; 65:2455.
* Original article (Subscription may be required)
* Medline abstract (Free)
裏面有10%的人從沒住過院(這種也會…)
全文找不到，不知道MDR的定義
Prevalence of Multidrug-Resistant Gram-Negative Pathogens
Fecal carriage of such pathogens was common among patients hospitalized for diarrhea in France, particularly those with recent hospitalization, antibiotic therapy, or nursing home residence.
A rapid rise in multidrug-resistant (MDR) gram-negative pathogens has been observed worldwide. Such pathogens can be acquired under common circumstances — for example, during travel (JW Infect Dis Sep 29 2010) — and antibiotic therapy is assumed to be the selective pressure driving further spread of resistant clones. Fecal colonization may be a risk factor for subsequent clinically apparent infections. However, little is known about the prevalence of MDR pathogens in the fecal flora of patients admitted to the hospital.
To investigate this issue, researchers collected stool specimens from 303 patients who were hospitalized in France with acute diarrhea during a nonoutbreak situation in the fall of 2009. The specimens were screened for gram-negative bacilli resistant to at least three antibiotic families. These bacteria were isolated using selective growth media and were further characterized by molecular methods.
Ninety-six patients (32%) harbored such MDR pathogens. Among these patients, 90% had been hospitalized, had been treated at a healthcare center, or had lived in a nursing home during the previous year; 59% had been prescribed antibiotics during the previous month. However, 10% of those carrying MDR bacteria had never been hospitalized before. Sixteen percent of the study population carried extended-spectrum β-lactamase–producing strains, and 5% carried carbapenemase-producing strains. The most commonly isolated MDR pathogens were Enterobacter cloacae and Escherichia coli.
Comment: Fecal colonization with MDR bacteria appears to be far more widespread than previously thought. The high level of fecal carriage has enormous potential for further selection of resistant clones in the course of antibiotic therapy and underlines the importance of proper hygiene measures to prevent the rapid spread of MDR pathogens.
— Thomas Glück, MD
Published in Journal Watch Infectious Diseases December 15, 2010
Citation(s):
Vidal-Navarro L et al. Faecal carriage of multidrug-resistant Gram-negative bacilli during a non-outbreak situation in a French university hospital. J Antimicrob Chemother 2010 Nov; 65:2455.
* Original article (Subscription may be required)
* Medline abstract (Free)
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