ICH 2010年 guidelines

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https://docs.google.com/fileview?id=0B278nGJMQBk7Zjc4YzA2OTAtMzNkYi00NzBjLTllMjctMDE0ZDE2MTgzMTU2&hl=zh_TW

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即便是用IGRA, 有時也要等大於三個月才能決定TB contact

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接觸TB後，TST大抵上2-12週轉陽，IGRA大抵上6-10週，但IGRA可以長到3個月以上 TB Tests Can Have a Lengthy Window Period Two studies suggest that interferon- release assay conversion sometimes occurs more than 3 months after exposure to active tuberculosis. Increasingly, interferon- release assays (IGRAs) are being used for diagnosing latent tuberculosis (TB). Although the tuberculin skin test (TST) traditionally used for this purpose converts to positive within 2 to 12 weeks after an individual is exposed to someone with active TB, the interval for IGRA conversion has remained unclear. Current guidelines recommend repeating an initially negative IGRA after 6 to 10 weeks, but this recommendation is not based on controlled studies. Two recent investigations address this issue. Anibarro and colleagues conducted a longitudinal prospective analysis among contacts of TB patients in Spain. The 152 contacts received a TST and an IGRA at first visit; for individuals with negative or conflicting results, t
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TG無用論，不用吃fenofibrate了，除非> 500mg/dl

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不用管TG levels，除非高到>500 好好吃東西，好好運動，比吃藥重要!! Don't Miss the New AHA Recommendations on Triglycerides A new scientific statement raises the threshold for pharmacologic treatment of hypertriglyceridemia. The following was published as a "Voices" blog on CardioExchange , an online forum for cardiology news and discussion. The blog prompted a lively conversation, which you can access and join by registering for CardioExchange. I've been surprised at the lack of fanfare surrounding the American Heart Association's recently published scientific statement on triglycerides and cardiovascular disease (CVD). The attention it did receive focused on the lower fasting triglyceride level that is now considered optimal: <100 mg/dL. In my opinion, the real headline was the committee's important statements in support of less drug treatment — in particular, the recommendation for a substantial increase in the triglyceride level that should trigger consideratio
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