所以scanol會增加青少年asthma.....多國研究，夠強大嗎?

多國研究喔! odds ratio 1.43 -> 2.51
還是一句老話" randomized controlled trials are now urgently required to investigate this relationship further"
這和ARB和lung cancer的關係一樣，is it junk science? Let's wait and see

Oxidant-induced airway inflammation and enhanced Th2 T-cell responses are potential mechanisms to account for these effects.
(那其它NSAID不會嗎?)

36萬個小朋友，來自113個國家，看影帶，填問卷…會不會是URI的症狀當做是asthma? conjunctivitis? URI會吃scanol 啊!


Acetaminophen Linked to Asthma in Adolescents


Current acetaminophen use seems associated with asthma in adolescents, according to a cross-sectional study in the American Journal of Respiratory and Critical Care Medicine.


Researchers surveyed some 360,000 13- and 14-year-olds in 50 countries about their recent (within 1 year) use of acetaminophen and their experience of symptoms of asthma, rhinoconjunctivitis, and eczema. They found an exposure-dependent risk for current asthma symptoms, with an odds ratio of 1.43 for medium use (at least once yearly) and 2.51 for high use (at least once monthly) compared with no use. Similarly, rhinoconjunctivitis and eczema were associated with recent use.


Oxidant-induced airway inflammation and enhanced Th2 T-cell responses are potential mechanisms to account for these effects.


The authors caution that with their design, "it is not possible" to prove a causal association, and conclude that "randomized controlled trials are now urgently required to investigate this relationship further."


[Editor's note: Although the journal has released this article from embargo, it has not posted the article on its website. We have provided a link to the journal's "articles in press" page, where it should appear shortly.]

https://docs.google.com/fileview?id=0B278nGJMQBk7NWNhMjg2OTctNjIxZC00NTZjLTk5ZWMtOGY0ZWNkYjE0YzU0&hl=zh_TW

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