TB新藥，診斷方法，和疫苗

每次去衛生所講都講個案，個案講來講去就是社會因素不聽話，不然就是太老，身體太差，副作用一堆，大概就是這樣，老病沒有新把戲
為了不被人家笑是騙錢
把東西看了一下

TAG report 2010(treatment action group)

對於HIV, viral hepatitis, TB 最近的pipeline做整理
沒有看得很清楚，不過似乎有很多TB vaccine的經費(61%)，自2008年後，是由BMGF(Bill Gates)的基金會捐助的，所以2008年後TB vaccine的研究突飛猛進，有錢好辦事

https://docs.google.com/fileview?id=0B278nGJMQBk7MzlhMzk5ZDgtZWQ0Yi00NWMyLTk1MDMtMzAyZjNmMzM2ODYw&hl=zh_TW

2009 結核病年報

https://docs.google.com/fileview?id=0B278nGJMQBk7YzZiM2I4MTAtYWE3ZC00ZjZlLTk3NDgtNGQwYjljNTkxMmMz&hl=zh_TW

荷蘭利用RFLP做smear negative TB和smear positive TB的比較，smear negative TB造成的TB infection佔 12.6%, 傳染力是smear positive TB的24%

https://docs.google.com/leaf?id=0B278nGJMQBk7MjQ0NjljNDgtNzRkNy00NjA4LTg4MmQtNmNjOTViOGMzNWZi&hl=zh_TW

TB pleurisy 利用 sputum induction, 仍有一半的病人sputum TB culture 會陽性

https://docs.google.com/fileview?id=0B278nGJMQBk7NmU2NGExZTUtNmEwMy00MjRkLWEwY2ItMDgxZmE3NWNjNjdh&hl=zh_TW

https://docs.google.com/present/edit?id=0AW78nGJMQBk7ZGc1d3FjYmpfMjQ5cDlyNnBiY20&hl=zh_TW

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這個網誌中的熱門文章

即便是用IGRA, 有時也要等大於三個月才能決定TB contact

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接觸TB後，TST大抵上2-12週轉陽，IGRA大抵上6-10週，但IGRA可以長到3個月以上 TB Tests Can Have a Lengthy Window Period Two studies suggest that interferon- release assay conversion sometimes occurs more than 3 months after exposure to active tuberculosis. Increasingly, interferon- release assays (IGRAs) are being used for diagnosing latent tuberculosis (TB). Although the tuberculin skin test (TST) traditionally used for this purpose converts to positive within 2 to 12 weeks after an individual is exposed to someone with active TB, the interval for IGRA conversion has remained unclear. Current guidelines recommend repeating an initially negative IGRA after 6 to 10 weeks, but this recommendation is not based on controlled studies. Two recent investigations address this issue. Anibarro and colleagues conducted a longitudinal prospective analysis among contacts of TB patients in Spain. The 152 contacts received a TST and an IGRA at first visit; for individuals with negative or conflicting results, t
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白宮為了掌控醫療費用，傾向大型醫療，個體戶勢必受挫

所以一旦政府介入，中外醫療提供者都傾向大型化…… independent practice -> dreaming 診所評鑑??應該擋住! http://www.medscape.com/viewarticle/727420 Physicians Say White House Should Not Write Off Small Practices August 24, 2010 — In a newly published article, the White House is advising physicians to accept a life in Big Medicine — as a hospital employee or member of a large group practice — in the wake of healthcare reform. Some leaders of organized medicine, however, are objecting to the government message. "We're not ready to write off the small practices," J. Fred Ralston Jr, MD, president of the American College of Physicians, told Medscape Medical News. "We think there needs to be more than one delivery model." "America is not a one-size-fits-all country," added M. Todd Williamson, MD, a neurologist from Lawrenceville, Georgia, and spokesperson for a coalition of medical societies opposed to the new healthcare reform law, now called the Affordable Care Act. Dr. Ralston and Dr.
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老美接受LTBI treatment的人，不到一半完治，和duration成正比

This study shows that although acceptance of LTBI treatment is relatively high (83%), the proportion completing is low (47%). When the product of these two proportions is calculated, we see that completion was achieved by only 39% of persons who were offered LTBI treatment. The major risk factor for noncompletion was being prescribed the 9-month INH regimen. As shown in Figure 1, when the proportions completing the three most commonly prescribed regimens are compared, it can be seen that there is an inverse relationship between length of the regimen prescribed and the proportion completing treatment. The increased completion that we observed with the 4-month rifampin regimen is consistent with previous reports.[18–20] It is of interest to note that if completion of the 9-month regimen were defined as completion of at least 6 months of INH, the noncompletion rate of the 9-month regimen, 42.9%, would have been almost identical to that of the 6-month regimen, 44.8%. Thus, prescribing the
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